A Non-Political Post!

 Time for a Senolytics Update



*


In 2011, scientists from the Kogod Center on Aging (part of Mayo) published research that was named a "Top 10" discovery by the journal Science. The findings, which were published in the journal Nature, proved the role of senescent cells in the aging process. 

I may have seen that in 2011, but I can’t be sure.


But in 2017 I got all giddy over the discoveries about senescent cells and the experimental therapies to reduce their negative impacts on health among us aging types.  (Search "senolytics" on this blog to see many giddy posts.)


HEADLINE: Over the Last Five Years Progress Has Been Steady


In the mad rush to find a key to the money vault that awaits successful anti-aging or healthspan extending substances, the scientists turning start-ups and the big established labs working on senolytics that will sell, are specializing in those senescent cells that cause or boost specific diseases. (The FDA doesn't treat aging as a disease.) (Although who knows, with RFK Jr. at the helm? Ooops, slightly political.)


WARNING!  AI CHATBOT BLAST.

  • Unity Biotechnology:
    • They have been a prominent player in senolytics, focusing on small molecule drugs.
    • They have conducted trials related to osteoarthritis and ophthalmological conditions.
  • Cleara Biotech:
    • They are focused on developing senolytics, with a strong emphasis on targeting senescent cells involved in fibrosis.
  • Oisin Biotechnologies:
    • They are developing gene therapy approaches to eliminate senescent cells.
  • Senolytic Therapeutics:
    • This is a company focused on the development of senolytic drugs.

Academic Institutions:

  • Mayo Clinic:
    • The Mayo Clinic has been a leader in senolytics research, with numerous clinical trials investigating the effects of senolytics on various age-related conditions.
    • They have conducted trials related to frailty, osteoarthritis, and other conditions.
  • Wake Forest University:
    • They have done research into senolytics, and have conducted clinical trials.
  • University of Texas Health Science Center at San Antonio:
    • They are involved in aging research, and senolytic research.

Other Organizations and Considerations:

  • National Institutes of Health (NIH):
    • The NIH funds research on aging and senolytics, and supports clinical trials through various grants.
  • Supplements and "Nutraceuticals":
    • While not all are formal clinical trials, there's growing interest in the potential senolytic effects of certain natural compounds like fisetin and quercetin.
    • However, it's essential to be cautious about claims made regarding these substances, and to consult with a healthcare professional.

Foundations Supporting Aging Research (Including Senolytics):

  • Buck Institute for Research on Aging:
    • This is a prominent independent research organization dedicated to extending the healthy lifespan.
    • They conduct extensive research on cellular senescence and related areas, and receive funding from various private sources.
  • AFAR (American Federation for Aging Research):
    • AFAR is a major non-profit organization that supports aging research, including work on senolytics.
    • They provide grants and awards to researchers studying the biology of aging.
  • SENS Research Foundation:
    • This foundation focuses on developing therapies to reverse aging-related damage, including cellular senescence.
    • They support research aimed at repairing the molecular and cellular damage associated with aging.
WHEW! Most of this AI answer seems to check out, but check it yourself, always on the alert for "hallucinations."

I and my AI pals will try to catch the top stories in all this and pass 'em along.

*FoY by Bing 





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