SeniorJunior

(Theory Belief/Hope about)  Aging Itself The Geroscience Hypothesis Duff, another of your rants on senolytics? In a nutshell:  Aging is caused by many things, but the buildup of senescent cells as we age is one that is both a CAUSE and and EFFECT of aging. Circular, no?  As time goes by, compounding damage happens to cells that causes them to become senescent -- no more dividing and replicating but they don't die,  they just hang around and emit SASP* which has inflammatory and other nasty molecules that speed up that long slide to death by "natural causes."**  Old people build up a LOT of senescent cells. They weaken the immune system that clears them out in younger people, more circular deterioration. GETTING RID OF SENESCENT CELLS WILL POSTPONE THAT.  ` As I read more about it,  I started blasting out blog posts in late 2017 . I was smitten by this paragraph: “Aging is the main risk factor for many chronic degenerative diseases and cancer. Increased...

I TOLD YOU ABOUT THIS SIX YEARS AGO (Surely you remember ?)  ...And in those six years, multiple research projects have affirmed and reaffirmed that SENOLYTICS is a big deal. The science of senolytics: how a new pill could spell the end of ageing                                    * I'm reminded of this by a well-researched article in The Guardian , a newspaper I respect. Aside from that hyperbolic, click-bait-ish headline, it's a fair summary of the state of knowledge on the subject. In brief: Certain drugs and several supplements help the body get rid of senescent cells, "zombie cells" that don't die after they quit doing their thing and just hang around spitting out inflammatory chemicals that damage various organs, joints, and brain cells. The senolytic agents augment apoptosis , nature's way of killing off the senescent cells. When those senescent cells are gone, things start improving m...