This Could Be Even Huger!

A Nasal Spray That Refurbishes Brains! 

The Hits Just Keep On Coming!

  Brain foggy          Sniff snort          Fog gone!   

                          

It works!   Ok, only on mice so far, but it's looking good.  Not kidding, I am. Here it is in incomprehensible medical english:

RESEARCH ARTICLE

Open Access

Intranasal Human NSC-Derived EVs Therapy Can Restrain Inflammatory Microglial Transcriptome, and NLRP3 and cGAS-STING Signalling, in Aged Hippocampus

TRANSLATION:

A 2026 study from Texas A&M University (Gig 'em Aggies!) tested a nasal spray delivering extracellular vesicles (EVs)—tiny biological particles carrying regulatory molecules. Delivered through the nose, these vesicles can bypass the blood–brain barrier and reach brain tissue directly.

In aging mice, the treatment:

Reduced chronic brain inflammation (“neuroinflammaging”)

Improved mitochondrial (cell energy) function  >Improved memory performance on behavioral tests  >University tested a nasal spray delivering extracellular vesicles (EVs)—tiny biological particles carrying regulatory molecules.  >Delivered through the nose, these vesicles can bypass the blood–brain barrier and reach brain tissue directly.

In aging mice, the treatment:Reduced chronic brain inflammation (“neuroinflammaging”)
Improved mitochondrial (cell energy) function Improved memory performance on behavioral tests 

Downright Optimism (rare these days)

"One day, the approach could even help stroke survivors rebuild lost brain function, or slow — even reverse — the effects of cognitive aging in humans."

I'll stay on top of this one and report any story advances.

BTW, check the names of the scientists doing this work, and mention your conclusions the next time someone says "we need to get those dang foreigners out of the country."

Leelavathi N. Madhu, Maheedhar Kodali, Shama Rao, Sahithi Attaluri, Raghavendra Upadhya, Goutham Shankar, Bing Shuai, Yogish Somayaji, Shruthi V. Ganesh, Vignesh S. Kumar, Jeswin E. James, Padmashri A. Shetty, Avery LeMaire, Xiaolan Rao, James J Cai, Ashok K. Shetty … See fewer authors 

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CREDIT:  3 pix of same guy getting his brain burst:  ChatGPT, from this prompt:

Three-panel photo-realistic portrait of the same elderly man, side by side, 

white background. Left panel: he looks downbeat, confused, 

slightly lost expression, dull eyes. Center panel: he is spraying nasal 

spray up one nostril, looking skeptical and doubtful. Right panel: he looks 

noticeably brighter, eyes almost sparkling, genuine happy expression. 

Same man, same clothing, same lighting in all three panels. 

Photographic style, soft studio lighting. 

Claude Opus 4.7 helped me write it. 

Amazing.