SeniorJunior

(Theory Belief/Hope about)  Aging Itself The Geroscience Hypothesis Duff, another of your rants on senolytics? In a nutshell:  Aging is caused by many things, but the buildup of senescent cells as we age is one that is both a CAUSE and and EFFECT of aging. Circular, no?  As time goes by, compounding damage happens to cells that causes them to become senescent -- no more dividing and replicating but they don't die,  they just hang around and emit SASP* which has inflammatory and other nasty molecules that speed up that long slide to death by "natural causes."**  Old people build up a LOT of senescent cells. They weaken the immune system that clears them out in younger people, more circular deterioration. GETTING RID OF SENESCENT CELLS WILL POSTPONE THAT.  ` As I read more about it,  I started blasting out blog posts in late 2017 . I was smitten by this paragraph: “Aging is the main risk factor for many chronic degenerative diseases and cancer. Increased...

See? I Told You to Bone Up on Senolytics [OK, this is more mouse research... but exciting!] Published Wednesday, 19 September in Nature Magazine ... one of the Super Journals (meaning they are as credible as they come, science-journal-wise), a paper based on research done at Mayo Clinic , a pretty good outfit.   Published:  19 September 2018 Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline If you keep up on Alzheimer's research, you recognize "tau-dependent," and if you don't, you surely know about cognitive decline. That and memory loss are the heart-ripping Alzheimer's symptoms we'd all like to avoid.  If You Are Interested in the Science Put your science hat on and take a look at the abstract (free) in Nature . Or read a (also free) layperson version.  Here's a short one (written for Big Pharma money men).                           ...

First follow-up on " Anti-aging pills aplenty " ** I started taking “life extension” supplements about a year ago. About time. I’m 80. Here them are: Nicotinamide Riboside 300mg/day Trans-Resveratrol 100mg 3/2days Pterostilbene 100mg 3/2days quercetin 800mg/day (“3/2days” means that I take those two every night, and alternating between them every morning. I take the NR every morning and the quercetin morning and night.) This little mix is what’s new in my fairly wide-spectrum and ever evolving “regular” supplements mix. I’ve been doing one variation or another of that for almost 60 years. One of these days, I’ll run over that list and tell you why I use each one. Fascinating stuff; I’m sure you can’t wait. I started with NR based on the reading I referenced here . Added in Pterostilbene after I realized my first NR product Basis by Elysium had it, so I added it as a solo ingredient when I tried Live Cell Research’s Niagen - straight NR.* Trans-re...