SeniorJunior

  Time for a Senolytics Update * In 2011 , scientists from the Kogod Center on Aging (part of Mayo) published research that was named a "Top 10" discovery by the journal Science. The findings, which were published in the journal Nature, proved the role of senescent cells in the aging process.  I may have seen that in 2011, but I can’t be sure. But in 2017 I got all giddy over the discoveries about senescent cells and the experimental therapies to reduce their negative impacts on health among us aging types.   (Search "senolytics" on this blog to see many giddy posts.) HEADLINE: Over the Last Five Years Progress Has Been Steady In the mad rush to find a key to the money vault that awaits successful anti-aging or healthspan extending substances, the scientists turning start-ups and the big established labs working on senolytics that will sell, are specializing in those senescent cells that cause or boost specific diseases. (The FDA doesn't treat aging as a diseas...

Getting All Flowery. And  Ayurvedic   New Front Opened in the War On Aging - Telomerase Adding a new substance to the brew of my "life extension" (anti-aging) formula. It's a hobby. The little end-caps on your DNA are telomeres. They wear out or fall off letting the DNA leak all over the kitchen floor which is an aging experience. Telomerase keeps the telomeres functional.  One supplement outfit that I subscribe to,  LiveCellResearch.com scans credible research and puts together attractive supplement combinations based on recent findings. They  aggressively market with well written emails. Since they reference a lot sources - and I check them - I find them c redible.  I give them the credit for turning me onto this combination. (They sell a Cadillac version, but I started out with the Pontiac version.) Ashwagandha    The Big brand in India, " Tranqualine" is the Caddy concentrate KSM-66 (LCR.com uses it). Their site came up under...

The Mice Were Right * NR (Nicotinamide Rhiboside) is the current star supplement in the Longer-Healthier-Life category (see piece below), but the vast majority of actual scientific testing of the vitamin has been on mice (and yeast, but hey...). Now real scientists have tested it on real people and reported in a real, peer reviewed journal, Nature Communications , part of the British behemoth, Nature . It's a small-sample study, but impressive nonetheless.  It is a part safety/side effects study and part proof-of-concept one. The news is all good. Even at four times what was thought to be the "regular" dosage, there are zero short term side effects.  And the presumed effect (seen in mice and yeast) of boosting the helpful NAD+ is clearly proven in humans. If you are into reading incomprehensible biochemistry, check it out here . You can read a less intimidating summary of what NAD+ does  here . BUT WAIT, THERE'S MORE! Next up in aging fixes is Senes...