SeniorJunior

(Theory Belief/Hope about)  Aging Itself The Geroscience Hypothesis Duff, another of your rants on senolytics? In a nutshell:  Aging is caused by many things, but the buildup of senescent cells as we age is one that is both a CAUSE and and EFFECT of aging. Circular, no?  As time goes by, compounding damage happens to cells that causes them to become senescent -- no more dividing and replicating but they don't die,  they just hang around and emit SASP* which has inflammatory and other nasty molecules that speed up that long slide to death by "natural causes."**  Old people build up a LOT of senescent cells. They weaken the immune system that clears them out in younger people, more circular deterioration. GETTING RID OF SENESCENT CELLS WILL POSTPONE THAT.  ` As I read more about it,  I started blasting out blog posts in late 2017 . I was smitten by this paragraph: “Aging is the main risk factor for many chronic degenerative diseases and cancer. Increased...

Forbes, the fanboy magazine for billionaire$...  ...had two " SENOLYTIC " pieces on Sept  24. I'm betting most of the rich people read both of them: 40,993 views Sep 24, 2018, 02:16am Senolytic Therapies Seem To Stop Alzheimer's Disease 'In Its Tracks' Robin Seaton Jefferson And... 4,745 views Sep 24, 2018, 02:16am Senolytic Therapies And The Quest To Cure Aging Robin Seaton Jefferson I posit the proposition (har, har) that ALL rich people are interested in living the longest, healthiest lives money can buy.  Lo, I have held forth thereon. So that was one reason they all read both pieces. The other of course can be heard in, "Alexa, buy a bloc of common in the following pharmaceuticals." Always looking for an edge of any kind.  Those darn rich people. This is good for us in the lower 95% Having an affluent, eager crowd of customers just waiting for the new product...

See? I Told You to Bone Up on Senolytics [OK, this is more mouse research... but exciting!] Published Wednesday, 19 September in Nature Magazine ... one of the Super Journals (meaning they are as credible as they come, science-journal-wise), a paper based on research done at Mayo Clinic , a pretty good outfit.   Published:  19 September 2018 Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline If you keep up on Alzheimer's research, you recognize "tau-dependent," and if you don't, you surely know about cognitive decline. That and memory loss are the heart-ripping Alzheimer's symptoms we'd all like to avoid.  If You Are Interested in the Science Put your science hat on and take a look at the abstract (free) in Nature . Or read a (also free) layperson version.  Here's a short one (written for Big Pharma money men).                           ...