Searching for Good News

A Ray of Hope

in 
A VERY credible source.

This line caught my eye: "...potential utility as an effective antiviral against SARS-CoV-2"
You can call me Novel

Every week I read Science Magazine cover-to-cover.  It's one of the 'gold standard' journals.  The world's scientific research output is prodigious.  I find hope in that.

   

Put on your science specs and plow through this bit of promising research. 


Abstract 

Coronaviruses (CoVs) traffic frequently between species resulting in novel disease outbreaks, most recently exemplified by the newly emerged SARS-CoV-2, the causative agent of COVID-19. Herein, we show that the ribonucleoside analog β-D-N4-hydroxycytidine (NHC, EIDD-1931) has broad spectrum antiviral activity against SARS-CoV-2, MERS-CoV, SARS-CoV, and related zoonotic group 2b or 2c Bat-CoVs, as well as increased potency against a coronavirus bearing resistance mutations to the nucleoside analog inhibitor remdesivir. In mice infected with SARS-CoV or MERS-CoV, both prophylactic and therapeutic administration of EIDD-2801, an orally bioavailable NHC-prodrug (β-D-N4-hydroxycytidine-5′-isopropyl ester), improved pulmonary function, and reduced virus titer and body weight loss. Decreased MERS-CoV yields in vitro and in vivo were associated with increased transition mutation frequency in viral but not host cell RNA, supporting a mechanism of lethal mutagenesis in CoV. The potency of NHC/EIDD-2801 against multiple coronaviruses and oral bioavailability highlight its potential utility as an effective antiviral against SARS-CoV-2 and other future zoonotic coronaviruses.

Now buckle up and skim the whole piece, and see if doesn't sound good to you.


Comments

Post a Comment

Popular posts from this blog

Scooter Duff's Theory of Cosmology [A work in progress]

Image
 [Olde Duff Gets Seriouser] SUPERMASSIVE BLACK HOLES  ARE MOSTLY PRIMORDIAL  DARK MATTER [Draft 8/19/2023] THE BIG NEWS.. ..Is from the James Webb Space Telescope. There were furiously active galaxies very soon after the Big Bang, not that long after the first generation stars happened. This implies supermassive black holes at the centers of the new galaxies.  The question, "how did these giant black holes get there so early?" seems not quite answered by the two main contenders, "Giant dust collapse," and "Many stellar black holes consolidating." Thus I decided to toss this hat into the ring: At the big bang, and dark matter was the first matter of any kind to form (perhaps during the mysterious “inflation” event -- my personal theory).  It’s mutual gravitational attraction and lack of interaction to any electromagnetic force allowed it to exist and start to coalesce, even in the heat of the BB, long before baryonic matter could.  There was a vast quantity
Read more

Rick and Morty

Image
A Millenial Hit Olde Folks Don't Know About Are you over 50? Have you ever heard about "Rick and Morty?" I thought not. There is a "cell" of younger people who love the show and say extravagant things about its wonderfulness. In these times when prior punditry had it we would be unified by some mysterious power in the Internet, there are more and more cells of people, unified within their cells, but isolated from most of the other cells of special interests*, tastes and proclivities.  The U.S. looks more like a pomegranate than a cantaloupe - to push the fruit/melon analogy to its extreme. I will dream up a graphic one of these days. USA, USA! society in fruit form. ANYHOO... I watched Rick and Morty at my millennial son's suggestion, and I LOVE IT. Eccentric old genius and non-genius grandson as the lead characters (faintly Back to the Future -esque) + sci-fi + Simpsons sensibilities +  intelligent satire + over-the-top imaginative creators
Read more

An Informational Present

Image
I TOLD YOU ABOUT THIS SIX YEARS AGO (Surely you remember ?)  ...And in those six years, multiple research projects have affirmed and reaffirmed that SENOLYTICS is a big deal. The science of senolytics: how a new pill could spell the end of ageing                                    * I'm reminded of this by a well-researched article in The Guardian , a newspaper I respect. Aside from that hyperbolic, click-bait-ish headline, it's a fair summary of the state of knowledge on the subject. In brief: Certain drugs and several supplements help the body get rid of senescent cells, "zombie cells" that don't die after they quit doing their thing and just hang around spitting out inflammatory chemicals that damage various organs, joints, and brain cells. The senolytic agents augment apoptosis , nature's way of killing off the senescent cells. When those senescent cells are gone, things start improving measurably (see the mouse with the young look in the Guardian piece.)
Read more