It's the Age Avalanche! (apologies to Ken Dychtwald).
Big changes are thundering down the time track. We will be the political gorilla. How do we use our muscle to the best effect? We have to be very careful and very smart.
We are the readers of Science Fiction, and now our world is sci-fi realized.
More Fountain of Youth Stuff -UPDATED
One More Word to Learn - In the Growing Jungle of Med-words:
That’s a class of drugs (and of some dietary supplements)
that specializes in cleaning out the senescent cells that build
up in your bod.
Here from “NATURE Communications” is a taste of the reason
this cleaning out is a good idea:
“Aging is the main risk factor for many chronic degenerative diseases and cancer. Increased senescent cell burden in various tissues is a major contributor to aging and age-related diseases. Recently, a new class of drugs termed senolytics were demonstrated to extending healthspan, reducing frailty and improving stem cell function in multiple murine models of aging.”*
OK, I'm a little senescent.
That “extending healthspan” business caught my attention.
My 80 year old brain (almost 81!) likes the sound of that.*
The drugs getting a lot of attention are in a class of "HSP90 Inhibitors"
and they wipe up senescent cells quite nicely. There's a lot of
excitement about how this will improve us old folks' lives by beating
back some of the chronic b.s. that drives us into nursing homes. I'm
pulling for Pharma to get this baby tested and in our formularies!
The Non-Drug Senolytic Natural Substances
While we wait for the HSP90 Inhibitors to come to our pharmacies, there are
substances you can get from your supplement suppliers right now.
As Pub-Med puts it:
"There are examples of promising natural compounds that appear to satisfy all the requirements to develop senescence- targeted health promoting nutraceuticals. Tocotrienols (T3s) and quercetin (QUE), albeit belonging to different phytochemical classes, display similar and promising effects "in vitro" when tested in normal and cancer cells. Both compounds have been shown to induce senescence and promote apoptosis in a multitude of cancer lines. Conversely, they display senescence delaying activity in primary cells and rejuvenating effects in senescent cells."**
I PREDICT (I love predicting) that quercetin is going to become a hot supplement,
taken by NFL players, distance runners, aging plutocrats and everyone in
Synolytics to clean out your grubby senescent cells, and to impress your friends
with a word they never heard of.
And from the Mayo Clinic:
By Megan Forliti
Mayo Clinic researchers review the clinical potential of senolytic drugs on aging
ROCHESTER, Minn. — Researchers are moving closer to realizing the clinical potential of drugs that have previously been shown to support healthy aging in animals. In a review article published online in the Journal of the American Geriatrics Society, Mayo Clinic aging experts say that, if proven to be effective and safe in humans, these drugs could be “transformative” by preventing or delaying chronic conditions as a group instead of one at a time.
The drugs being tested are called senolytic agents, because they target senescent cells. These are cells that have stopped dividing and secrete toxic chemicals that damage adjacent cells. Accumulation of senescent cells, which increases with age, is associated with chronic conditions, including diabetes, cardiovascular disease, most cancers, dementia, arthritis, osteoporosis, and frailty.***
Prologue and Thirty-eight Chapters Written, Produced and Read by Olde Scooter Give it a shot HERE.
...All together in sequence, a "playlist" concoction on YouTube.
Click HEREfor the whole enchilada (all 38 chapters of the enchilada - as in "the whole")
You can either "Play All" and the book will roll out in proper order, or if you want to listen to a particular chapter, just click it, and it will play through the remaining chapters.
(Since the recording is made as a YouTube video, the audiobook part is just the audio track. The visual is a vid place holder. Try to ignore it.
SUPPORT OLD GUY SCI-FI If you know a sci-fi fan or somebody looking for a free audio book, please refer them here, or "share" if it's no trouble. Thanks a bunch!
“Mental Health,” the Excuse for Never Having Gun Regulationby a Clinical Psychologist [The gun issue is frequently discussed among my friends. This blog post was written by one pal, with credentials out the juazoo.]
"The List," Folks Too Crazy to Buy a Gun The emphasis on mental health makes me crazy...no pun intended. A list of people too dangerous to have guns because of their mental health? That assumes such diagnosis is possible. It’s not. The most difficult thing to predict is if someone is actually going to "act" on his/her mental condition. It’s functionally almost impossible. When a clinician is seriously concerned that a patient is at some risk for suicidal or homicidal behavior, it is NOT the first thing you do to report him to the Feds. You contact family and make sure there are no firearms in the home. But are you going to put every depressed person on a watch list? Which disorders beyond depression are you going to include...psychoses like schizophrenia, o…